View PubMed


  • Di Luccia B, Gilfillan S, Cella M, Colonna M*, Huang SC*­. ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands. Journal of Experimental Medicine, 2019 [PMID: 31296736].

  • Jarjour NN, Schwarzkopf EA, Bradstreet TR, Shchukina I, Lin CC, Huang SC, Lai CW, Cook ME, Taneja R, Stappenbeck TS, Randolph GJ, Artyomov MN, Urban, Jr. JF, Edelson BT. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nature Immunology, 2019; 20: 687-700. [PMID: 31061528]

  • Li X, Wenes M, Romero P, Huang SC, Fendt SM, Ho PC. Navigating metabolic pathways to enhance antitumour immunity and immunotherapy. Nature Reviews Clinical Oncology, 2019; 16: 425-441. [PMID: 30914826]


  • Sanin DE, Matsushita M, Geltink RIK, Grzes KM, Bakker NVT, Corrado M, Kabat AM, Buck MD, Qiu J, Lawless SJ, Cameron AM, Villa M, Baixauli F, Patterson AE, Hässler F, Curtis JD, O’Neill CM, O’Sullivan D, Wu D, Mittler G, Huang SC, Pearce EL, Pearce EJ. Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2. Immunity, 2018; 49: 1021-1033. [PMID: 30566880]

  • Bando JK, Gilfillan S, Song C, McDonald KG, Huang SC, Newberry RD, Kobayashi Y, Allan DS, Carlyle JR, Cella M, Colonna M. The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells. Immunity, 2018; 48: 1-12. [PMID: 29858011]


  • Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M. TREM2 maintains microglial metabolic fitness in Alzheimer’s disease. Cell, 2017; 170(4): 649-663. [PMID: 28802038]

  • Cheng CC, Chang J, Huang SC, Lin HC, Ho AS, Lim KH, Chang CC, Huang L, Chang YC, Chang YF, Wu CW. YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells. PLoS One, 2017; 12(8):e0182149. [PMID: 28787001]


  • Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KH, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi M, Urano F, Ory DS, Schaffer JE. RpL13a small nucleolar RNAs regulate systemic glucose metabolism. Journal of Clinical Investigation, 2016; 126(12): 4616-4625. [PMID: 27820699]

  • Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ. Metabolic reprogramming mediated by the mTORC2-IRF4 axis is essential for macrophage alternative activation. Immunity, 2016; 45(4): 817-830. [PMID: 27760338]

  • Kannan Y, Perez-Lloret J, Li Y, Entwistle LJ, Khoury H, Papoutsopoulou S, Mahmood R, Mansour NR, Huang SC, Pearce EJ, de Carvalho LP, Ley SC, Wilson MS. TPL-2 regulates macrophage lipid metabolism and M2 differentiation to control Th2-mediated immunopathology. PLoS Pathogens, 2016; 12(8):e1005783. [PMID: 27487182]

  • Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metabolism, 2016; 24(1): 158-166. [PMID: 27374498]

  • Buck MD, O’Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O’Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming. Cell, 2016; 166(1): 63-76. [PMID: 27293185]

  • Everts B, Tussiwand R, Dreesen L, Fairfax KC, Huang SC, Smith AM, O’Neill CM, Lam WY, Edelson BT, Urban JF Jr, Murphy KM, Pearce EJ. Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12. Journal of Experimental Medicine, 2016; 213(1): 35-51. [PMID: 26712805]


  • Hewitson JP, Filbey KJ, Esser-von Bieren J, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Huang SC, Yang L, Tu Y, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM. Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection. PLoS Pathogens, 2015; 11(3): e1004676. [PMID: 25816012]

  • Jha A, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN. Network integration of parallel metabolomics-transcriptional data reveals novel metabolic modules regulating divergent macrophage polarization. Immunity, 2015; 42(3), 419-430. [PMID: 25786174]

  • Pearce EJ, Huang SC. The metabolic control of schistosome egg production. Cellular Microbiology, 2015; 17(6): 796-801. [PMID: 25850569]


  • Nascimento M, Huang SC, Smith A, Everts B, Lam W, Bassity E, Gautier EL, Randolph GJ, Pearce EJ. Ly6C+ monocyte recruitment is responsible for macrophage accumulation in Th2 associated hepatic inflammation during schistosomiasis. PLoS Pathogens, 2014; 10(8): e1004282. [PMID: 25144366]

  • Huang SC, Pearce EJ. For Macrophages, Ndufs is Enough. Immunity, 2014; 41(3): 351-353. [PMID: 25238092]

  • Huang SC, Everts B, Ivanova Y, O’Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O’Neill CM, Yan C, Du H, Abumrad NA, Urban JF Jr, Artyomov MN, Pearce EL, Pearce EJ. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nature Immunology, 2014; 15(9): 846-855. [PMID: 25086775]

  • O’Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity, 2014; 41(1), 75-88. [PMID: 25001241]

  • Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW. Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter. Science, 2014; 345(6196): 573-577. [PMID: 24968940]

  • Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. Journal of Experimental Medicine, 2014; 211(8): 1525-1531. [PMID: 25024137]

  • Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation. Nature Immunology, 2014; 15(4), 323-332. [PMID: 24562310]


  • van der Windt GJ, O'Sullivan D, Everts B, Huang SC, Buck MD, Curtis JD, Chang CH, Smith AM, Ai T, Faubert B, Jones RG, Pearce EJ, Pearce EL. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc Natl Acad Sci USA, 2013; 110(35), 14336-14341. [PMID: 23940348]

  • Taylor CM, Wang Q, Rosa BA, Huang SC, Powell K, Schedl T, Pearce EJ, Abubucker S, Mitreva M. Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways. PLoS Pathogens, 2013; 9(8): e1003505. [PMID: 23935495]

  • Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O’Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL. Post-transcriptional control of T cell effector function by aerobic glycolysis. Cell, 2013; 153(6): 1239-1251. [PMID: 23746840]


  • Huang SC, Freitas TC, Amiel E, Everts B, Pearce EL, Lok JB, Pearce EJ. Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni. PLoS Pathogens, 2012; 8(10):e1002996. [PMID: 23133378]

  • Fairfax K, Nascimento M, Huang SC, Everts B, Pearce EJ. Th2 response in schistosomiasis. Seminars in Immunopathology, 2012; 34(6): 863-871. [PMID: 23139101]

  • Galanti SE, Huang SC, Pearce EJ. Cell death and reproductive regression in female Schistosoma mansoni. PLoS Negl Trop Dis, 2012; 6(2):e1509. [PMID: 22363825]

  • Selkirk ME, Huang SC, Knox DP, Britton C. The development of RNA interference (RNAi) in gastrointestinal nematodes. Parasitology, 2012; 139(5): 605-612. [PMID: 22459433]


  • Huang SC, Chan DT, Smyth D, Ball G, Gounaris K, Selkirk ME. Activation of Nippostrongylus brasiliensis larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum. International Journal for Parasitology, 2010; 40(14): 1619-1628. [PMID: 20654619]