Research in our laboratory focuses on understanding the interplay between cellular signaling and metabolic regulation that dictate immune cell activation during inflammation.

The goals of our work are to determine the specific environmental cues, nutrient changes and/or unusual metabolites that can control the metabolic and epigenetic programs to selectively impact innate immunity in inflammatory diseases and cancer.

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A brief introduction of macrophage phenotype including research timelines, the pathways and functional of inflammatory and anti-inflammatory phenotype.

This Nature Video shows the complexity of Innate lymphoid cell (ILC) biology in the gut mucosa at steady state and disease.